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言語
英語
著者
三宅 仁美 島根大学医学部内科学第一
金沢 一平 島根大学医学部内科学第一
杉本 利嗣 島根大学医学部内科学第一
内容記述(抄録等)
Objective: Previous studies have shown that serum insulin-like growth factor-I (IGF-I) is involved in diabetes-related bone fragility. Although lower serum levels of IGF-I are reported to be associated with a higher risk of vertebral fractures in patients with type 2 diabetes, it is unknown whether or not the serum level of IGF-I is associated with the incidence of non-vertebral fractures.
Methods: We investigated the relationships between the serum levels of IGF-I and the incidence of non-vertebral osteoporotic fractures in 188 men and 168 postmenopausal women with type 2 diabetes.
Results: A multiple logistic regression analysis adjusted for age, duration of diabetes, observation period, body mass index, HbA1c, serum creatinine, and the bone mineral density at the lumbar spine showed that the serum IGF-I level was significantly and inversely associated with the incidence of non-vertebral osteoporotic fractures in postmenopausal women (odds ratio =0.48, 95% confidential interval [CI] 0.23-0.99 per SD increase; p=0.047), but not in men. Moreover, the inverse association between the serum IGF-I level and the incidence of non-vertebral fractures remained significant after additional adjustment for insulin use, and the serum calcium and phosphate levels (odds ratio =0.48, 95% CI 0.23-0.99 per SD increase; p=0.046).
Conclusion: This is the first study to show that decreased serum IGF-I levels are associated with a higher risk of non-vertebral osteoporotic fractures in postmenopausal women with type 2 diabetes. Serum IGF-I could be a useful marker for assessing the incidence of osteoporotic fractures.
主題
insulin-like growth factor-I
type 2 diabetes mellitus
fracture
non-vertebral fractures
掲載誌名
Internal medicine
56
3
開始ページ
269
終了ページ
273
ISSN
13497235
発行日
2017-02-01
DOI
PubMed ID
NCID
AA12022491
出版者
Japanese Society of Internal Medicine
出版者別表記
日本内科学会
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
Copyright © 2017 by The Japanese Society of Internal Medicine
部局
医学部
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