DNase II Polymorphisms (2630T>C (Ser145Ser) and 2901G>A (VaI206Ile)) in Japanese From Shimane Prefecture, Koreans, and Three Africans

Recently, SNPs and hap10types in the DNase 11 gene were shown to be associated with renal disorder in SLE patients. In this study, DNASE2*Ser145Ser and DNASE2 *Va1206Ile polymorphisms were determined by using the PCR-RFLP technique in healthy subjects of Japanese, Koreans, Ovambos, Ghanaians, and Xhosans (n=871). For DNASE2*Ser145Ser, the Japanese and Korean populations exhibited higher 2630T frequencies than the Ovambos, Ghananians, and Xhosans, whose allele frequencies were higher for 2630C. Population data from the HapMap Project showed similar allele frequencies. For DNASE2 * Va1206Ile, Koreans were the only population with the DNASE2*VaI206Ile polymorphism. A previous study revealed an association with the risk of renal disorders in Korean SLE patients and the DNASE2 * Ser145Ser polymorphism. In this study, we verified significant ethnic diversity in the DNASE2*Ser145Ser polymorphisms. It is questionable whether a correlation between the risk of renal disorder in SLE patients and the DNASE2*Ser145Ser polymorphism exists in populations other than the Korean population.