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ファイル
言語
英語
著者
寺嶋 正治
Shimoyama, Makoto
内容記述(抄録等)
Actin, a major constituent in all eukaryotic cells, is one of the most important components of cytoskeletal architecture, and is involved in a numerous cellular processes including phagocytosis, cell locomotion, and maintenance of cell shape. These functions depend on the capacity of actin to polymerize and depolymerize. We previously reported that chicken arginine-specific ADP-ribosyltransferase ADP-ribosylated globular (G-) and filamentous (F-) actins, and that the modification of G-actin inhibited its capacity to polymerize i,1 vitro and in situ, suggesting the involvement of ADP-ribosylation in regulation of the cytoskeletal organization in vivo. In the present study, we demonstrated that ADP-ribosylation of F-actin resulted in the depolymerization of the actin. Thus, ADP-ribosylation may have a role to shift G-F actin equilibrium toward the G-actin through the modification of both G- and F-actins, and participate in the regulation ofcytoskeletal reorganization.
掲載誌名
Shimane journal of medical science
17
2
開始ページ
37
終了ページ
41
ISSN
03865959
ISSN(Online)
24332410
発行日
1999-12-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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