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公開日 : 2017-07-18
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著者
山本 昌弘 島根大学医学部内科学第一
杉本 利嗣 島根大学医学部内科学第一
内容記述(抄録等)
Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), which are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. On the other hand, these compounds biologically act as agonists for these receptors for AGEs (RAGE) and suppress bone metabolism. The concentrations of AGEs and endogenous secretory RAGE, which acts as a “decoy receptor” that inhibits the AGEs-RAGE signaling axis, are associated with fracture risk in a BMD-independent manner. AGEs are closely associated with the pathogenesis of this unique clinical manifestation through physical and biological mechanisms in patients with diabetes mellitus.
主題
Fracture
Bone quality
Material properties
Pentosidine
Crosslink
Receptor for advanced glycation end products (RAGE)
掲載誌情報
Current osteoporosis reports 14 ( 6 ), 320 - 326 , 2016-12
出版者
Current Science
権利関係
© The Author(s) 2016. This article is published with open access at Springerlink.com
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