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ファイル
言語
英語
属性
原著論文
著者
多田納 豊
清水 利朗
富岡 治明
内容記述(抄録等)
Immunosuppressive macrophages (Mφs) generated in the spleen of Mycobacterium intracellulare (Min)-infected mice (Min-Mφs) exhibit suppressor activity against T cell mitogenesis in response to concanavalin A. Here, we attempted to fractionate the Min-Mφs population generated in Min-infected BALB/c mice at week 2 after infection. Min-Mφs were found to consist of two distinct subpopulations differing in their adhesiveness to plastic wells. The strongly adhesive Mφs population (SA-Mφs) exhibited marked suppressor activity. The weakly adhesive Mφ population (WA-Mφs) exhibited much less suppressor activity. Both SA-Mφs and WA-Mφs possessed a CDllb+F4/80+SR-AI+CDl4+ CD206+ phenotype characteristic of matured Mφs, generated reactive oxygen intermediates, and suppressed IL-2 receptor expression by concanavalin A-stimulated T cells. Moreover, their suppressor activities were dependent on prostaglandin. These findings indicate that Min infection in mice generates two types of immuosuppressive Mφs with different levels of suppressor activity.
掲載誌名
Shimane journal of medical science
26
開始ページ
1
終了ページ
7
ISSN
03865959
ISSN(Online)
24332410
発行日
2009-12-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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