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ファイル
言語
英語
属性
原著論文
著者
Yang Jianjun
Mutombo Paulin Beya wa Bitadi
岩本 麻実子
乃木 章子
塩飽 邦憲
内容記述(抄録等)
As the gene-gene or gene-environment interactions on obesity are unresolved, we investigated the ACE I/D, UCP1 -3826 A/G, α_(2B)-ADR Glu^(12)/Glu^9, β_3-ADR Trp64Arg, and PON1 Q192R genotypes at the baseline and after a lifestyle-modified intervention for body mass index(BMI). A total of 212 Japanese adults lowered their BMI 0.8 ± 0.8kg/ m^2 over three months. The I/D + D/D genotypes of ACE had significantly higher BMI compared to the I/I genotype at the baseline, but there were no significant differences for the other four genetic polymorphisms and the addictive effects of these genetic polymorphisms. The I/D + D/D genotypes of ACE induced greater reduction of BMI. Greater weight-loss in the D allele group remained after adjustment for age, sex, BMI at the baseline, energy balance and the other four genetic polymorphisms. The I/D + D/D genotypes of ACE had significantly higher BMI at the baseline, but induced weight-loss through the lifestyle intervention, as compared to the I/I genotype.
主題
BMI
ACE
UCPI
α_(2B)-ADR
β_3-ADR
PONI
lifestyle modification
掲載誌名
Shimane journal of medical science
29
1
開始ページ
1
終了ページ
12
ISSN
03865959
ISSN(Online)
24332410
発行日
2012-12-01
NCID
AA00841586
出版者
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
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