ダウンロード数 : 59

公開日 : 2024-05-23
1.63 MB

著者
内容記述(抄録等)
There are two types of vascular smooth muscle contraction. One is normal contraction, which is physiological and Ca2+-dependent. Another is abnormal contraction, which causes vasospasm and Ca2+-independent. Rho-kinase and PKC are known key molecules to mediate the signal transduction of abnormal vascular smooth muscle contraction. Sphingosylphosphorylcholine (SPC) is a member of sphingolipids and induces Ca2+-independent, Rho-kinase-mediated abnormal vascular smooth muscle contraction via the activation of Src family tyrosine kinase (Src-TK). We found SPC-induced contraction is cholesterol-dependent and suggest the involvement of membrane raft in the signal transduction of abnormal vascular smooth muscle contraction mediated by SPC/Src-TK/Rho-kinase pathway. Eicosapentaenoic acid specifically inhibited abnormal vascular smooth muscle contraction through the inhibition of SPC/Src-TK/Rho-kinase pathway. By functional proteomics, we identified cytoskeleton-related proteins as the candidate of novel molecule to mediate abnormal vascular smooth muscle contraction and investigating their interaction with Rho-kinase. We hope that this interaction could be a new drug target.
主題
vascular smooth muscle contraction
functional proteomics
cytoskeleton-related proteins
掲載誌情報
Shimane Journal of Medical Science 41 ( 1 ), 1 - 7 , 2024-03
出版者
Faculty of Medicine, Shimane University
権利関係
Faculty of Medicine, Shimane University
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