ダウンロード数 : ?
ファイル
言語
英語
著者
Sugimoto, Naotoshi Department of Physiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan
片倉 賢紀
内容記述(抄録等)
Previous research has shown that habitual chocolate intake is related to cognitive performance and that frequent chocolate consumption is significantly associated with improved memory. However, little is known about the effects of the subchronic consumption of dark chocolate (DC) on cognitive function and neurotrophins. Eighteen healthy young subjects (both sexes; 20–31 years old) were randomly divided into two groups: a DC intake group (n = 10) and a cacao-free white chocolate (WC) intake group (n = 8). The subjects then consumed chocolate daily for 30 days. Blood samples were taken to measure plasma levels of theobromine (a methylxanthine most often present in DC), nerve growth factor (NGF), and brain-derived neurotrophic factor, and to analyze hemodynamic parameters. Cognitive function was assessed using a modified Stroop color word test and digital cancellation test. Prefrontal cerebral blood flow was measured during the tests. DC consumption increased the NGF and theobromine levels in plasma, enhancing cognitive function performance in both tests. Interestingly, the DC-mediated enhancement of cognitive function was observed three weeks after the end of chocolate intake. WC consumption did not affect NGF and theobromine levels or cognitive performance. These results suggest that DC consumption has beneficial effects on human health by enhancing cognitive function
主題
dark chocolate
theobromine
nerve growth factor
cognitive function
subchronic effect
young-adult
Stroop color word test
digital cancellation test
掲載誌名
Nutrients
11
11
ISSN
2072-6643
発行日
2019-11-16
DOI
出版者
MDPI
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e37054
部局
医学部
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