ダウンロード数 : ?
ファイル
言語
英語
著者
下浦 惠子
Kakizoe, Eiichi
Yokoyama, Satoshi
Wang, Dan-Qiao
奥西 秀樹
内容記述(抄録等)
Previous studies in rats demonstrated that the inhibition of vascular tissue angiotensin-converting enzyme (ACE) was the determinant of antihypertensive action
of an ACE inhibitor, whereas plasma ACE inhibition was not. In patients, however, it is not practical to perform vascular tissue-biopsy merely to estimate drug effects. Therefore, the present study examined in rats practical to perform vascular tissue-biopsy merely to estimate drug effects. Therefore, the present study examined in rats whether or not peripheral blood lymphocytes (PBL) could be used as a surrogate marker for aortic tissue in respect of tissue ACE inhibition. Rats were treated daily for 6 days with one of the three ACE inhibitors (captopril, enalapril, and trandolapril) bearing different pharmacokinetic properties from each other. At a certain time after the final dosing, PBL and various tissues were harvested to measure ACE activity ex vivo. The present results confirmed the previous data for ACE inhibition in aorta and other tissues. Unexpectedly, however, ACE activity ex vivo of PBL was not reduced at all by any of the drug treatments, suggesting some drug-efflux mechanisms involved. In conclusion, PBL could not be used as the surrogate marker to estimate the vascular tissue ACE inhibition.
掲載誌名
Shimane journal of medical science
18
2
開始ページ
43
終了ページ
52
ISSN
03865959
ISSN(Online)
24332410
発行日
2000-12-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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