ダウンロード数 : ?
ファイル
言語
英語
属性
Original article
著者
JERIN, Sultana Jannatul Ferdoush
MAMUNUR, Rahman
AO, Gong
内容記述(抄録等)
Major depression (MD) is the most prevalent mood disorder worldwide. Electroconvulsive treatment (ECT) is a highly effective treatment in psychiatry and shows efficacy in patients who were resistant to pharmacotherapy. Recent retrospective cohort studies have shown that ECT is highly effective in ameliorating depressive symptoms. Similar ECT efficacy has been established also in various rodent models of MD. To establish further efficacy of ECT in rodent depression models, we investigated the effect of ECT on depressive-like behaviour induced by lipopolysaccharide (LPS) in rats. Methods: Adult male Sprague-Dawley (SD) rats were randomly divided into four groups, namely, control, LPS, sham ECT, and LPS + ECT. The SD rats received intraperitoneal injection of LPS or sterile saline, followed by ECT or sham treatment for 7 consecutive days. Subsequently, the forced swimming test (FST) and Y-maze test were performed. Results: The FST showed that the immobility time in the LPS group (169.73 ± 15.46 s) was significantly longer than that in the control group (63.16 ± 4.48 s). However, ECT administration to LPS-injected rats significantly shortened the prolonged immobility. The Y-maze test showed a significant decrease in % spontaneous alternation behaviour (SAB) in the LPS group compared to the control group. ECT administration to LPS-injected rats significantly restored such a decrease in % SAB. Conclusions: Our results suggest that repeated ECT ameliorated LPS-induced depressive-like behaviour in SD rats. Further studies are warranted to elucidate the molecular mechanism of such therapeutic effects of ECT.
主題
major depression
electroconvulsive treatment
depressive-like behaviour
lipopolysaccharide
forced swimming test
Y-maze test
掲載誌名
Shimane Journal of Medical Science
39
3
開始ページ
105
終了ページ
112
ISSN
03865959
ISSN(Online)
24332410
発行日
2022-09
NCID
AA00841586
DOI
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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