ダウンロード数 : ?
ファイル
言語
英語
著者
Tie-Zhong Cui Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Japan
Tomohiro Kaino Department of Applied Bioscience and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Japan
内容記述(抄録等)
The length of the isoprenoid-side chain in ubiquinone, an essential component of the electron transport chain, is defined by poly-prenyl diphosphate synthase, which comprises either homomers (e.g., IspB in Escherichia coli) or heteromers (e.g., decaprenyl diphosphate synthase (Dps1) and D-less polyprenyl diphosphate synthase (Dlp1) in Schizosaccharomyces pombe and in humans). We found that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispBR321A mutant and restored IspB activity and production of Coenzyme Q-8. IspB interacted with Dlp1 (or Dps1), forming a high-molecular weight complex that stabilized IspB, leading to full functionality.
主題
Isoprenoid
Ubiquinone
Coenzyme Q
Prenyl diphosphate synthase
IspB
掲載誌名
FEBS Letters
584
4
開始ページ
652
終了ページ
656
ISSN
0014-5793
発行日
2010-2-19
DOI
出版者
Federation of European Biochemical Societies
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
著者版
業績ID
e9311
部局
生物資源科学部
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