ファイル | |
言語 |
英語
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著者 | |
内容記述(抄録等) | Brain-derived neurotrophic factor (BDNF) is expressed at high levels in the hippocampal dentate gyrus (DG), and decreased levels of BDNF have been implicated in the pathophysiology of schizophrenia (SCZ). We have previously reported that yokukansan (YKS), which is a traditional Japanese medicine, is effective for SCZ and promotes neurogenesis in the DG of Gunn rats, an animal model of SCZ. In this study, we investigated the effect of YKS on serum BDNF levels in Gunn rats. The results showed that YKS increased serum BDNF in this model, which may suggest that BDNF expression in the DG leads to increased neurogenesis. Our findings may help to explain the efficacy of YKS in treating SCZ.
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掲載誌名 |
脳科学誌
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巻 | 44
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開始ページ | 34
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終了ページ | 41
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ISSN | 1341-5301
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ISSN(Online) | 2432-2512
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発行日 | 2014-12-30
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DOI | |
出版者 | 日本脳科学会
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出版者ヨミ | ニホン ノウカガッカイ
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出版者別表記 | Japan Brain Science society
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資料タイプ |
学術雑誌論文
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ファイル形式 |
PDF
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著者版/出版社版 |
出版社版
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業績ID | e26971
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部局 |
医学部
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