Excessive Extracellular ATP Desensitizes P2Y2 and P2X4 ATP Receptors Provoking Surfactant Impairment Ending in Ventilation-Induced Lung Injury

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言語	英語
著者	Hasan Djo Mobile Intensive Care Unit Zuid-West Nederland, 3062 NW Rotterdam, The Netherlands / Department of Surgery, Erasmus MC, Erasmus Universiteit Rotterdam, 3015 CE Rotterdam, The Netherlands Satalin Joshua Department of Surgery, Upstate Medical University, Syracuse, NY 13210, USA van der Zee Philip Adult Intensive Care Unit, Erasmus MC, Erasmus Universiteit Rotterdam, 3015 CE Rotterdam, The Netherlands Kollisch-Singule Michaela Department of Surgery, Upstate Medical University, Syracuse, NY 13210, USA Blankman Paul Department of Anesthesiology, Universitair Medisch Centrum Utrecht, 3584 CX Utrecht, The Netherlands Shono Atsuko Department of Anesthesiology, Shimane University, Izumo, Shimane Prefecture 693-0021, Japan Somhorst Peter Adult Intensive Care Unit, Erasmus MC, Erasmus Universiteit Rotterdam, 3015 CE Rotterdam, The Netherlands den Uil Corstiaan Adult Intensive Care Unit, Erasmus MC, Erasmus Universiteit Rotterdam, 3015 CE Rotterdam, The Netherlands / Department of Cardiology, Erasmus MC, Erasmus Universiteit Rotterdam, 3062 PA Rotterdam, The Netherlands Meeder Han Mobile Intensive Care Unit Zuid-West Nederland, 3062 NW Rotterdam, The Netherlands / Adult Intensive Care Unit, Erasmus MC, Erasmus Universiteit Rotterdam, 3015 CE Rotterdam, The Netherlands Kotani Toru Department of Anesthesiology and Critical Care Medicine, Showa University, School of Medicine, Tokyo 142-8666, Japan Nieman Gary F. Department of Surgery, Upstate Medical University, Syracuse, NY 13210, USA
主題	extracellular ATP; purinergic signaling; P2X receptors; P2Y receptors; surfactant dysfunction; ventilation-induced lung injury; innate immunity
掲載誌名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
巻	19
号	4
ISSN	1422-0067
発行日	2018-04
DOI	10.3390/ijms19041185
PubMed ID	29652806
出版者	MDPI
資料タイプ	学術雑誌論文
部局	医学部
備考	Djo Hasan: The author reports to have received an honorarium to a lecture from Demcon-Macawi; Michaela Kollisch-Singule: The author reports to have received travel reimbursement at events sponsored by Drager Medical; Gary F. Nieman.: The author reports to have received grants from the NIH, a grant from Drager Medical, a grant from the CDRMP (DoD), travel and honorarium to lecture from Drager Medical; Joshua Satalin, Philip van der Zee, Paul Blankman, Atsuko Shono, Peter Somhorst, Corstiaan den Uil, Han Meeder and Toru Kotani: The authors declare no conflicts of interest.