ダウンロード数 : ?
ファイル
言語
英語
属性
原著論文
著者
又賀 建太郎
青木 明彦
姫野 安敏
滋野 和志
鈴木 恵子
内容記述(抄録等)
Protein energy wasting, malnutrition-inflammation complex syndrome, and frailty are thought to affect mortality in chronic dialysis patients. We performed a historical cohort study to investigate effects of the nutritional status on cardiovascular (CV) and non-CV mortalities as well as CV events using Geriatric Nutritional Risk Index (GNRI). We registered patients undergoing maintenance hemodialysis (HD)therapy from January to March in 2006 to analyze mortality and causes of death in 7-years observation. A Kaplan-Meyer curve showed that the survival rate tends to be lower in 102 patients with GNRI<92, compared to 171 patients with GNRI ≧92. In a multivariate Cox proportional hazard analysis, the GNRI was an independent predictor for all-cause mortality with hazard ratio of 0.960 (95% confident interval: 0.928-0.993) after adjustment with age, gender, dialysis duration, blood access, the presence of diabetes mellitus, serum levels of calcium, phosphate, alkaline phosphatase, parathyroid hormone and C-reactive protein, and drug use of active vitamin D analog and non-calcium containing phosphate binders. The GNRI was not associated with CV death but with non-CV death after adjustment with the covariates. In parallel with these findings, there was no significant association between the GNRI and CV events. Nutritional status was significantly associated with non-CV death but not with CV death and CV events at least in our maintenance hemodialysis patients.
主題
nutrition
hemodialysis
mortality
cardiovascular event
掲載誌名
Shimane journal of medical science
33
2
開始ページ
61
終了ページ
70
並び順
2
ISSN
03865959
ISSN(Online)
24332410
発行日
2017-03-01
NCID
AA00841586
SID
9189
出版者
Shimane University Faculty of Medicine
DCMI
text
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
掲載誌コード
Shimane Journal of Medical Science
学位授与番号
甲第649号
学位授与年月日
2019-3-22
学位名
博士(医学)
学位授与機関
島根大学
学位論文研究科コード
医学系研究科
学位授与年度
2018
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