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ファイル
言語
英語
属性
Original article
著者
秋田 智后
手塚 綾乃
山下 親正
内容記述(抄録等)
The NAD+–sirtuin 1 (SIRT1) pathway is essential for neutrophil differentiation induced by the granulocyte-colony stimulating factor, and thus may contribute to neutropenia observed after cancer chemotherapies. This study aimed to investigate the relationship between neutropenia and indices for the activity of the NAD-SIRT1 pathway, i.e., nicotinamide phosphoribosyltransferase (NAMPT) activity and SIRT1 expression in patients receiving chemotherapy for lung cancer. Blood samples were collected from sixteen patients at the start of chemotherapy, at the nadir, and before the start of the second chemotherapy course. Neutrophil counts, NAMPT activity and SIRT1 expression level were measured. There were no differences observed either in NAMPT activity or in SIRT1 expression level between the cases of grade 3–4 neutropenia and those of grade 0–2 neutropenia though the SIRT1 expression level tended to decrease at the nadir. Further studies are required to elucidate this relationship between post-chemotherapy neutropenia and SIRT1 expression.
主題
chemotherapy
lung cancer
neutropenia
SIRT1 expression
掲載誌名
Shimane Journal of Medical Science
38
4
開始ページ
119
終了ページ
125
ISSN
03865959
ISSN(Online)
24332410
発行日
2021-12
NCID
AA00841586
DOI
DOI(SelfDOI)
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
権利関係(リンク)
著者版/出版社版
出版社版
部局
医学部
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