ダウンロード数 : ?
タイトルヨミ
クロロフォルム チュウドクセイ カンショウガイ ノ ジッケンテキ ケンキュウ 5 : ニンシン コウキ カト ノ クロロフォルム カンショウガイ
日本語以外のタイトル
An Experimental Study on Chloroform-toxic Liver Disturbance : V. Chloroform Hepatic Injury in Late Pregnant Rabbit
言語
日本語
著者
坂本 巌
飯田 幸司
村尾 文規
内容記述(抄録等)
To lnduce liver injury, the late pregnant rabbits were administered chloroform 0.5ml/kg body weight, subcutaneously twice at intervals of 48 hours.They were sacrificed 48 hours after the final administration of chloroform. These histological findings of the liver were compared with hepatic injurg of non-pregnant rabbits induced by chloroform in the same way. Hydropie degeneration, acidophilic degeneration and eosinophilic coagulative necrosis are the common response of the liver to chloroform poisoning These leslons were decreased in late pregnant rabbits as compared with non-pregnant rabbits, but central fatty degeneration was significantly increased in late pregnant rabblts. Tne size of fat droplet in these hepatic cells were small to medium and the deposition of fat in the lobul were central to peripheral zone. These histological appearances were quite like as the diagnosis of acute fatty liver in late human pregnancy, and it seems to suggest that the pathogenesis of fatty degeneration may be related to the specific fatty metabolism in late pregnancy.
主題
chloroform
肝障害
妊娠
hepatic injury
pregnancy
掲載誌名
島根医科大学紀要
11
開始ページ
45
終了ページ
51
ISSN
03879097
発行日
1988-12-01
NCID
AN00107602
出版者
島根医科大学
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
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