ダウンロード数 : ?
ファイル
言語
日本語
属性
原著論文
著者
長見 晴彦
田中 恒夫
矢野 誠司
原田 孝之
Nosaka, Seishi
Sato, Yoshitoshi
内容記述(抄録等)
 α-fetoprotein (AFP) gastric cancer is defined as a gastric cancer partially consisting of tumor cells producing AFP.
In the present study, we investigated the malignant potential of AFP producing gastric cancer (n=11) and AFP-non-producing gastric cancer (n=73).
The immunohistochemical expression of AFP was demonstrated in all specimens of AFP producing gastric cancer. However, it was not shown in all specimens of AFP non-producing gastric cancer. From the viewpoint of clinical pathology, the incidence of low-differentiated adenocarcinoma and liver metastasis was higher in AFP producing gastric cancer. The argyrophilic nuclear organizer region (Ag-NOR) score and area of AFP producing gastric cancer were 3.28±1.19 and 4.68±1.57u㎡, respectively, signifi-cantly (P<0.05) higher than those of AFP non-producing gastric cancer. On the other hand, the incidence of the aneuploid pattern of AFP producing gastric cancer was 80.0%, significantly (P<0.05) higher than that of AFP non-producing gastric cancer.
Moreover, the 4c exceeding rate (4cER), which is defined as the percentage of cells with an aneuploid nuclear DNA content over the tetraploid (4c) of AFP producing gastric cancer was 23.07±7.97%, significantly (P<0.05) higher than that of AFP non-producing gastric cancer.
In conclusion, the poor prognosis of patients with AFP producing gastric cancer may be attributed to the extremely malignant potential of neoplastic cells.
掲載誌名
Shimane journal of medical science
24
開始ページ
7
終了ページ
13
ISSN
03865959
ISSN(Online)
24332410
発行日
2007-12-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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