ダウンロード数 : ?
言語
英語
著者
Ito, Teruna 福島県立医科大学
Tsuji, Masayoshi 福島県立医科大学
Mori, Yayoi 福島県立医科大学
神田 秀幸 島根大学医学部環境保健医学講座
Hidaka, Tomoo 福島県立医科大学
Kakamu, Takeyasu 福島県立医科大学
Kumagai, Tomohiro 福島県立医科大学
Hayakawa, Takehito 福島県立医科大学
Osaki, Yoneatsu 福島県立医科大学
Fukushima, Tetsuhito 福島県立医科大学
内容記述(抄録等)
OBJECTIVES: Nicotine in cigarettes is metabolized primarily by CYP2A6-catalyzed oxidation. The CYP2A6*4 allele, in which CYP2A6 is a homozygous whole-deletion variant, completely lacks enzyme activity. The aim of this study was to examine the effects of CYP2A6*4 genetic polymorphism on smoking behavior and nicotine dependence in a general population of Japanese men.
METHODS: The subjects were 124 healthy Japanese men who gave informed consent to give saliva samples. The survey items included general information, smoking behaviors and nicotine dependence. The polymerase chain reaction restriction fragment length polymorphism method was used to analyze the genetic polymorphisms of CYP2A6. The subjects were classified into two groups: Group W (CYP2A6*4 absence: *1A/*1A, *1A/*1B and *1B/*1B) and Group D (CYP2A6*4 presence: *1B/*4A, *4A/*4A, *1A/*4A or *1B/*4D, and *1A/*4D). We analyzed the differences in the survey items between the two groups.
RESULTS: There were no significant differences in smoking behaviors between the two groups. However, Group D tended to have less difficulty in refraining from smoking after waking in the morning compared to Group W (p=0.051).
CONCLUSIONS: CYP2A6*4 genetic polymorphisms may not strongly affect smoking behavior but may possibly have an effect on nicotine dependence.
主題
CYP2A6
genetic polymorphism
smoking behavior
nicotine dependence
Japanese adult men
掲載誌名
Fukushima journal of medical science
61
2
開始ページ
125
終了ページ
130
ISSN
00162590
発行日
2015-12
DOI
PubMed ID
NCID
AA0065246X
出版者
Fukushima Society of Medical Science
出版者別表記
福島医学会
資料タイプ
学術雑誌論文
権利関係
Copyright © 2015 The Fukushima Society of Medical Science
部局
医学部
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