Previous studies have shown the pedagogical benefits of using virtual patient simulation (VPS), but there are no studies using simulators and VPS together, making learner satisfaction and learning effectiveness unknown. This study investigated the satisfaction level of the educational program using simulators and VPS. From April to November 2021, 60 fifth-year medical students participated in a small-group program. Cardiac auscultation training was done for 80 min. Thereafter, VPS was administered for 70 min. A questionnaire was distributed to evaluate the overall educational program, physical examinations, and VPS program. Ninety-eight percent of the students reported participation in group discussions, and 97% reported participation levels consistent with those in medical school over five years. The physical examination rating was the median (interquartile range): 1(1-1) and 1(1-2) for the VPS. Therefore, education combining a simulator and VPS can facilitate the process from examination to diagnosis, and afford a high satisfaction level.