Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(冊子体)
ISSN :2433-2410(オンライン)

クリエイティブ・コモンズ・ライセンス
これらの論文は クリエイティブ・コモンズ 表示 - 非営利 - 改変禁止 4.0 国際 ライセンスの下に提供されています。
ダウンロード数 : ?
Shimane Journal of Medical Science 39 1
2022-03 発行

Effect of Ninjin’yoeito on Lipopolysaccharide-Induced Depressive-Like Behavior and Glial Activation in the Hippocampus

JAYA, Muhammad Alim
林田 麻衣子
土江 景子
JERIN, Sultana Jannatul Ferdoush
MAMUNUR, Rahman
三浦 章子
宮岡 剛
TANRA, Andi Jayalangkara
堀口 淳
ファイル
内容記述(抄録等)
Depression is one of the most common mental disorders. Glial cells have been reported to play a role in the pathogenesis of depression. Meanwhile, Ninjin’yoeito (NYT), a Kampo medicine, is a multi-component drug that was reported to improve depressive symptoms in patient and animal models. In addition, some of its components have an effect on glial cells. However, the mechanism remains unclear. The study’s aim was to investigate the effect of NYT in recovering depressive-like behavior and glial pathological changes in the hippocampus induced by lipopolysaccharide. Here, we showed that NYT improved the forced swim test performances of the rat. Furthermore, NYT also inhibited microglial activation in the hippocampus, but the results were different in astrocytes. These results suggest that NYT alleviates depressive-like behavior, and the effect may be associated with the attenuation of glial cell activation.
DOI
権利関係(リンク)
権利関係
Faculty of Medicine, Shimane University