Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(冊子体)
ISSN :2433-2410(オンライン)

クリエイティブ・コモンズ・ライセンス
これらの論文は クリエイティブ・コモンズ 表示 - 非営利 - 改変禁止 4.0 国際 ライセンスの下に提供されています。
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Shimane Journal of Medical Science 22 1
2005-03-01 発行

Possible mechanism of hypothermia induced bu serum of a hypothermic patient in restrained rats

Sugimoto, Naotoshi
Asai, Akira
丸山 めぐみ
Koizumi, Shoichi
ファイル
内容記述(抄録等)
We experienced a patient who suffered from severe hypothermia. The etiology and mechanism of hypothermia were not known. Intraperitoneal (i.p.) injections of the patient's serum into restrained rats produced a significant hypothermia without associated changes in tail skin temperature. Heat balance of rats was then measured with direct and indirect calorimetry before and during the i.p. injection of the patient serum. The hypothermia induced by the patient's serum was associated with a reduction of oxygen consumption, but was not accompanied by changes in evaporative and nonevaporative heat loss. The results suggest that cryogenic substance(s), which was excessively produced in patient's blood, may affect thermogenic function and then produce hypothermia in rats.