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ファイル
言語
英語
属性
Review
著者
内容記述(抄録等)
Inhibitors of sodium–glucose cotransporter 2 (SGLT2) have undoubtedly shifted the paradigm for diabetes medicine and research and, especially, diabetic kidney disease (DKD). The pharmacological action of SGLT2 inhibitors is simply the release of glucose into urine; however, precisely how SGLT2 inhibitors contribute to the health of those with diabetes has still not been completely elucidated. Towards this end, the present review provides a novel insight into the action of SGLT2 inhibitors by highlighting a neglected fuel-burning system found in proximal tubular cells—‘glycolysis’. In addition, exploring the details of the molecular mechanisms and clinical biomarkers of the organ protection conferred by SGLT2 inhibitors is now required to prepare for the next stage of clinical diabetes medicine—the ‘post-SGLT2 inhibitor era’.
主題
Hypoxia-inducible factor
Glycolysis
PKM2
SGLT2
Sirt3
掲載誌名
Diabetes & Metabolism
46
5
開始ページ
353
終了ページ
361
ISSN
1262-3636
発行日
2020-09-03
DOI
出版者
Elsevier Masson SAS
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
著者版
業績ID
39755
部局
医学部
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