ダウンロード数 : ?
ファイル
言語
英語
著者
Tanaka, Ken-ichiro Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
Kanazawa, Ippei Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
Sugimoto, Toshitsugu Department of Internal Medicine 1, Shimane University Faculty of Medicine, Izumo, Japan
内容記述(抄録等)
Objective Sarcopenia has been recognized as a diabetic complication, and hyperuricemia is often accompanied by type 2 diabetes mellitus (T2DM). However, it is unknown whether serum uric acid (UA) levels are associated with reduced muscle mass in T2DM.

Methods We conducted a cross-sectional study to investigate the association of serum UA with muscle mass in 401 subjects with T2DM (209 men and 192 postmenopausal women). The relative skeletal muscle mass index (RSMI) was evaluated using whole-body dual-energy x-ray absorptiometry.

Results Multiple regression analyses adjusted for body weight, age, serum creatinine, hemoglobin A1c (HbA1c), and duration of T2DM showed that serum UA was negatively associated with RSMI in all subjects and men with T2DM (β=−0.13, p=0.001 and β=−0.17, p=0.003, respectively). Moreover, logistic regression analyses adjusted for these confounding factors showed that a higher serum UA level was significantly associated with low RSMI in men with T2DM [odds ratio (OR)=1.94, 95% confidence interval (CI)=1.10–3.45 per SD increase, p=0.023]. In addition, higher serum UA levels were significantly associated with low RSMI after additional adjustment for age, duration of T2DM, HbA1c level, serum creatinine level, and sex in all subjects with T2DM [OR=1.80, 95% CI=1.20–2.72 per SD increase, p=0.005].

Conclusions The present study showed for the first time that higher serum UA is an independent risk factor of reduced muscle mass in men with T2DM.
主題
uric acid
hyperuricemia
muscle mass
sarcopenia
diabetes mellitus
掲載誌名
Experimental and clinical endocrinology & diabetes
129
01
開始ページ
50
終了ページ
55
ISSN
0947-7349
ISSN(Online)
1439-3646
発行日
2018-12-12
DOI
出版者
Thieme
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
著者版
業績ID
39763
部局
医学部
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