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ファイル
言語
英語
著者
足立 康二
川上 耕史
内容記述(抄録等)
All-trans retinoic acid (ATRA) is valuable in differentiation therapy for acute promyelocytic leukemia (APL). However, ATRA has had limited success as a single agent, due to the development of resistance. We found that tamoxifen effectively enhanced the differentiation-inducing effect of ATRA. Tamoxifen alone inhibited the proliferation of myeloid leukemia cell lines while only slightly increasing morphologic differentiation. Tamoxifen effectively enhanced the growthinhibiting actions of various differentiation-inducing agents. ATRA in the presence of tamoxifen increased NBT reduction and the expression of CD11b in HL-60 cells more effectively than ATRA alone. Tamoxifen also enhanced the differentiation induced by the other inducers tested. ATRA induced the differentiation of APL cell lines NB4 and HT93 and APL cells in primary culture, and this differentiation was also enhanced by tamoxifen. Tamoxifen is one of the most widely used drugs for the treatment of cancer and has few side effects. The combination of ATRA and tamoxifen might be considered for the treatment of APL patients in whom it can be difficult to apply arsenic trioxide or anthracyclines.
主題
acute promyelocytic leukemia cells
differentiation
growth inhibition
tamoxifen
all-trans retinoic acid
掲載誌名
INTERNATIONAL JOURNAL OF ONCOLOGY
48
3
開始ページ
1095
終了ページ
1102
ISSN
1019-6439
発行日
2016
DOI
出版者
Spandidos Publications
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e30150
e29066
e28834
e29065
部局
医学部
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