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language
eng
Author
Ito, Teruna Fukushima Medical University School of Medicine
Tsuji, Masayoshi Fukushima Medical University School of Medicine
Mori, Yayoi Fukushima Medical University School of Medicine
Kanda, Hideyuki Department of Environmental Medicine and Public Health, Shimane University Faculty of Medicine
Hidaka, Tomoo Fukushima Medical University School of Medicine
Kakamu, Takeyasu Fukushima Medical University School of Medicine
Kumagai, Tomohiro Fukushima Medical University School of Medicine
Hayakawa, Takehito Fukushima Medical University School of Medicine
Osaki, Yoneatsu Fukushima Medical University School of Medicine
Fukushima, Tetsuhito Fukushima Medical University School of Medicine
Description
OBJECTIVES: Nicotine in cigarettes is metabolized primarily by CYP2A6-catalyzed oxidation. The CYP2A6*4 allele, in which CYP2A6 is a homozygous whole-deletion variant, completely lacks enzyme activity. The aim of this study was to examine the effects of CYP2A6*4 genetic polymorphism on smoking behavior and nicotine dependence in a general population of Japanese men.
METHODS: The subjects were 124 healthy Japanese men who gave informed consent to give saliva samples. The survey items included general information, smoking behaviors and nicotine dependence. The polymerase chain reaction restriction fragment length polymorphism method was used to analyze the genetic polymorphisms of CYP2A6. The subjects were classified into two groups: Group W (CYP2A6*4 absence: *1A/*1A, *1A/*1B and *1B/*1B) and Group D (CYP2A6*4 presence: *1B/*4A, *4A/*4A, *1A/*4A or *1B/*4D, and *1A/*4D). We analyzed the differences in the survey items between the two groups.
RESULTS: There were no significant differences in smoking behaviors between the two groups. However, Group D tended to have less difficulty in refraining from smoking after waking in the morning compared to Group W (p=0.051).
CONCLUSIONS: CYP2A6*4 genetic polymorphisms may not strongly affect smoking behavior but may possibly have an effect on nicotine dependence.
Subject
CYP2A6
genetic polymorphism
smoking behavior
nicotine dependence
Japanese adult men
Journal Title
Fukushima journal of medical science
Volume
61
Issue
2
Start Page
125
End Page
130
ISSN
00162590
Published Date
2015-12
DOI
PubMed ID
NCID
AA0065246X
Publisher
Fukushima Society of Medical Science
Publisher Aalternative
福島医学会
NII Type
Journal Article
Rights
Copyright © 2015 The Fukushima Society of Medical Science
OAI-PMH Set
Faculty of Medicine