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language
eng
Attribute
Original article
Author
HIRAYAMA, Nanae
ABE, Yumiko
Description
Drug delivery systems, drugs are administered into the amniotic fluid, may contribute to fetal therapy. The present study explored changes in the volume of amniotic fluid from E11.5 through E17.5, and kinetics of calcein-containing liposomal particles incubated in the amniotic fluid collected at E12.5, E14.5, and E16.5 in Jcl/ICR mice. The volume of amniotic fluid increased until E15.5, followed by a sharp decrease at E17.5. The calcein release rate remained within 4% until day 14 in serum and each amniotic fluid. No significant differences were noted in the release rate between the serum and amniotic fluid at various time points. Therefore, the calcein release rate of liposomal nanoparticles in the amniotic fluid remained low and did not differ from that in the serum for as long as 14 days at different time points during gestation. These observations suggest that liposomal nanoparticles remain stable for prolonged periods in the amniotic fluid.
Subject
liposomal particle
amniotic fluid
mouse
Journal Title
Shimane Journal of Medical Science
Volume
40
Issue
3-4
Start Page
55
End Page
60
ISSN
03865959
ISSN(Online)
24332410
Published Date
2023-12
NCID
AA00841586
DOI
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
rights(link)
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出版社版
OAI-PMH Set
Faculty of Medicine
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