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File
language
eng
Attribute
original article
Author
Akagi, Shuji
Nagaoka Kenji
Burgess Jefferey L
Shiwaku, Kuninori
Description
To evaluate the usability of biological monitoring of levels of exposure to N,N-dimethylformamide (DMF) vapor by urinary N-methylformamide(NMF), we conducted a study in a factory in which DMF is used in the production of artificial leather. Severe liver damage in the worker exposed to 3 liters of DMF liquid was evidenced by raised levels of AST, ALT, γ-GTP and urinary NMF(327 IU/l, 158 IU/l, 233 IU/l and 854 mg/l, respectively). A laparoscopy revealed the liver to be markedly deformed by extensive scarring. After this accident, we investigated the handling and management of DMF in this factory, and it revealed that, of workers engaged in the polymer coating section, 44% had over 40 mg/lof urinary NMF, and 32% had 10 to 40 mg/l, despite DMF concentrations in the air of less than 2.2 ppm. After changes of operational procedures by our intervention, the workers had over 40 mg/l and between 10 to 40 mg/l of urinary NMF decreased to 25% and 52%, respectively. Our occupational intervention revealed that urinary NMF concentration was a useful representative index of daily exposure to DMF in the factory.
Subject
N,N-dimethylformamide
urinary Nmethylformamide
biological monitoring
biologicalexposure index
liver damage
Journal Title
Shimane journal of medical science
Volume
32
Issue
2
Start Page
51
End Page
59
ISSN
03865959
ISSN(Online)
24332410
Published Date
2016
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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