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File
language
eng
Author
Hatta, Toshihisa
Tanaka, Osamu
Description
The amino acid sequence arginine-glycine-aspartate (RGD) acts as a specific ligand for integrins in cell adhesion. We injected RGD into the telencephalic vesicle of mouse embryos exo utero on E13 and examined the cortical histogenesis of the telencephalon on E15,16 and 18. RGD induced disorganized cytoarchitecture and reduced cell number in the cortical plate and intermediate zone. In the ventricular zone although there was no difference in cell density between RGD-injected brains and controls, mitotic activity analysis revealed the lower proliferative rate in RGD-injected brains. These results suggest that RGD-proteins or integrins play an important role both in the migration of neuroblasts and the proliferation of neuroepithelial cells during the cortical histogenesis of the telencephalon.
Subject
RGD peptide
Neurogenesis
Exo utero development
Mouse embryo
Journal Title
Shimane journal of medical science
Volume
14
Start Page
1
End Page
6
ISSN
03865959
ISSN(Online)
24332410
Published Date
1996
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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