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language
eng
Author
Yamaguchi, Toru
Nawata, Kiyoko
Tanaka, Ken-ichiro
Takaoka, Shin
Description
Although a high serum low-density lipoprotein cholesterol (LDL-C) level is an established risk factor for atherosclerosis, it is unclear whether it is associated with osteoporosis. In this study, the associations between the serum LDL-C level and bone mineral density (BMD), bone metabolic markers, and the presence of prevalent vertebral or non-vertebral fractures were examined. A total of 211 healthy postmenopausal women (age range, 46-80 years) who visited a community health center were recruited consecutively. Their radiographic and biochemical characteristics were collected. Prevalent vertebral and non-vertebral fractures were found in 49 (23.2 %) and 36 (17.1 %) subjects, respectively. Simple regression analyses showed that the serum LDL-C level was not significantly correlated with lumbar or femoral BMD or serum levels of total amino-terminal propeptide of type I collagen (PINP) or carboxy-terminal telopeptide of type I collagen (CTX). Logistic regression analyses adjusted for age and BMI showed that the increased serum LDL-C level was selected as an index affecting the presence of prevalent non-vertebral fractures, but not vertebral fractures. This result was still significant after additional adjustments for years since menopause, physical activity, previous cardiovascular events, bone markers, BMD, serum Ca, P, Cr, 25(OH)D, grip strength, tandem gait test, and use of drugs for hyperlipidemia [odds ratio 1.76 (1.13-2.73), p = 0.012]. These findings suggest that a high serum LDL-C level may be a risk factor for prevalent non-vertebral fragility fractures independent of bone turnover, bone mass, vitamin D insufficiency, or frail status in postmenopausal women, and that it may be detrimental to bone, as well as blood vessels.
Subject
Low-density lipoprotein cholesterol
Non-vertebral fracture
Osteoporosis
Postmenopausal women
Bone mineral density
Dislipidemia
Hypercholesterolemia
Vitamin D
Journal Title
Endocrine
Volume
48
Issue
1
Start Page
279
End Page
286
ISSN
15590100
Published Date
2015-02
DOI
DOI Date
2017-03-23
PubMed ID
NCID
AA12629840
Publisher
Springer
NII Type
Journal Article
Format
PDF
Rights
© Springer Science+Business Media New York 2014
Text Version
著者版
Gyoseki ID
e26990
e27138
OAI-PMH Set
Faculty of Medicine
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