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language
eng
Author
Yamori, Yukio
Ohtaka, Michiya
Nara, Yasuo
Horie, Ryoichi
Oshima, Akira
Endo Takeshi
Description
Spontaneously hypertensive rats (SHR) showed a mild deviation of glucose metabolism, as detected by glucose tolerance test (GTT).The morphological changes in the pancreatic islets of SHR may possibly be related to the hormonal alteration in genetic hypertension.In light of these experimental results GTT was applied for study in the following 3 groups of humans : the normotensives with or without a family history of cerebral stroke (5 each) and 5 hypertensives with no apparent secondary cause.
Higher serum glucose and insulin levels were obtained et 1 hour of GTT both in the hypertensives and the normotensives with a family history of cerebral stroke.
Serum lipid levels were altered by glucose administration, particularly serum cholesterol level was decreased by about 10 mg/dl at 1 hour after glucose administration both in rats and humans, with or without hypertension.
The slight intolerance detected by GTT in genetic hypertension both in rats and humans may be used as a parameter in the detection of genetic predisposition to hypertension or cerebral stroke.
Subject
hypertension
glucose tolerance
insulin
Journal Title
Shimane journal of medical science
Volume
2
Issue
2
Start Page
124
End Page
132
ISSN
03865959
ISSN(Online)
24332410
Published Date
1978-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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