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File
language
eng
Attribute
original article
Author
Yang Jianjun
Mutombo Paulin Beya wa Bitadi
Iwamoto, Mamiko
Nogi, Akiko
Shiwaku, Kuninori
Description
As the gene-gene or gene-environment interactions on obesity are unresolved, we investigated the ACE I/D, UCP1 -3826 A/G, α_(2B)-ADR Glu^(12)/Glu^9, β_3-ADR Trp64Arg, and PON1 Q192R genotypes at the baseline and after a lifestyle-modified intervention for body mass index(BMI). A total of 212 Japanese adults lowered their BMI 0.8 ± 0.8kg/ m^2 over three months. The I/D + D/D genotypes of ACE had significantly higher BMI compared to the I/I genotype at the baseline, but there were no significant differences for the other four genetic polymorphisms and the addictive effects of these genetic polymorphisms. The I/D + D/D genotypes of ACE induced greater reduction of BMI. Greater weight-loss in the D allele group remained after adjustment for age, sex, BMI at the baseline, energy balance and the other four genetic polymorphisms. The I/D + D/D genotypes of ACE had significantly higher BMI at the baseline, but induced weight-loss through the lifestyle intervention, as compared to the I/I genotype.
Subject
BMI
ACE
UCPI
α_(2B)-ADR
β_3-ADR
PONI
lifestyle modification
Journal Title
Shimane journal of medical science
Volume
29
Issue
1
Start Page
1
End Page
12
ISSN
03865959
ISSN(Online)
24332410
Published Date
2012-12-01
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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