Serum dopamine-β-hydroxylase (DBH) activities in 94 male and 93 female normal subjects and of 36 subjects with chronic hepatic disorders were measured. The activities in normal subjects were distributed widely and were not normal in shape but skewed. There was no significant difference in serum DBH activity according to age or sex. There was no difference in serum DBH activity between normal subjects and hepatic disorders. In hepatic disorders there were significant positive correlations between DBH and GOT or AlP, suggesting a possible correlation between enhancement of serum DBH activity and development of hepatic disorders.