Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(冊子体)
ISSN :2433-2410(オンライン)

クリエイティブ・コモンズ・ライセンス
これらの論文は クリエイティブ・コモンズ 表示 - 非営利 - 改変禁止 4.0 国際 ライセンスの下に提供されています。
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Shimane Journal of Medical Science 5 1
1981-06-01 発行

Lithium Distribution and Regional Serotonin Metabolism in the Brain of Dogs under Prolonged Lithium Intoxication

光信 勝甫
Ebara, Takashi
渡辺 昌祐
ファイル
内容記述(抄録等)
The regional distribution of lithium (Li) and changes in serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels were examined after dogs had been maintained under conditions of chronic Li intoxication for prolonged periods. The distributions of Li were uneven in the brain. The amygdala, thalamus and hippocampus showed the highest levels, the inner capsule, diencephalon, midbrain, cerebral gray matter, cerebral white matter, medulla and pons contained intermediate levels, while the lowest levels were detected in the cerebellum and spinal cord. There were considerable variations in these levels among the individual dogs. 5-HT levels were decreased significantly in the medulla (to 55% of the control), cerebral gray matter (to 63%) and cerebral white matter (to 75%), and 5-HIAA levels were also decreased significantly in the pons (to 17%), lenticular nucleus (to 42%), cerebellum (to 42%) and inner capsule (to 68%). Correlations between the Li ion levels and the extent of the regional 5-HT or 5-HIAA decrease were nil. The extent of the decrease in the levels of these compounds seems to be dependent not on the Li levels but rather on the vulnerability of each brain region.