Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(冊子体)
ISSN :2433-2410(オンライン)

クリエイティブ・コモンズ・ライセンス
これらの論文は クリエイティブ・コモンズ 表示 - 非営利 - 改変禁止 4.0 国際 ライセンスの下に提供されています。
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Shimane Journal of Medical Science 39 3
2022-09 発行

Spatial Organization of Chromatin Structure in the Central Nervous System

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内容記述(抄録等)
The genome is carried by the complete linear sequence of DNA nucleotides packaged into all the chromosomes. During interphase, the chromosomes are extended and much of their chromatin exist as long threads while also maintaining specific three-dimensional architectures in the nuclear space. These interphase chromosomes are organized into multiscale three-dimensional structures, including chromosome territories, A/B compartments, topologically associating domains, and chromatin loops, that extend over a wide range of genomic distances, providing connections, for instance, between enhancers and promoters. This hierarchically organized genomic architecture is crucial for the regulation of gene transcription, which in turn is essential for the development and maintenance of various biological processes. This article reviews various aspects of spatial genome organization and their functions in gene expression and neural development. Furthermore, dysregulation of spatial genome organization in disease states, and the growing interest in new technologies to manipulate chromatin architecture are also discussed.
DOI
権利関係(リンク)
権利関係
Faculty of Medicine, Shimane University