Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(冊子体)
ISSN :2433-2410(オンライン)

クリエイティブ・コモンズ・ライセンス
これらの論文は クリエイティブ・コモンズ 表示 - 非営利 - 改変禁止 4.0 国際 ライセンスの下に提供されています。
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Shimane Journal of Medical Science 22 2
2005-12-01 発行

Dietary effects of docosahexaenoic acid on spatial cognition learning ability in rats fed N-3 fatty acid-adequate diet

橋本 道男
Haque, Abdul Md.
Sugioka, Kozo
片倉 賢紀
ファイル
内容記述(抄録等)
Twenty-two 5-week-old male Wistar rats fed an n-3 fatty acid-adequate diet were supplemented with docosahexaenoic acid (DHA) administered perorally for 14 weeks. Six weeks after the start of the administralion, the rats were for 5 weeks trained to acquire a reward at the end of each of 4 arms of an 8-arm radial maze. The retention test interposed with a delayed task (20-min interval after acquiring the first 2 rewards) was then given to each rat to determine spatial working memory retention DHA administration reduced the number of working memory errors after the 20-min interval in the retention test and tended to induce an increase in the DHA/arachidonic acid ratio in the hippocampus, indicating that chronic administration of DHA to rats fed an n-3 fatty acid-adequate diet is conducive to the improvement of working memory-related learning abiiity.