Shimane Journal of Medical Science

Shimane University Faculty of Medicine
ISSN :0386-5959(冊子体)
ISSN :2433-2410(オンライン)

クリエイティブ・コモンズ・ライセンス
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Shimane Journal of Medical Science 14
1996 発行

Innervation of human developing extraocular muscles : immunohistochemical study

大国 昌美
瀬戸川 朝一
田中 修
篠原 春夫
加藤 兼房
ファイル
内容記述(抄録等)
S-100 protein has two subunits, S-100α and S-100β. S-100α is predominant in neurons and slow-twitch muscle fibers, while S-100β exists in glial cells and Schwann cells. In the present study, the presence of S-100α and S-100β was investigated immunohistochemically in the extraocular muscles of 15 human embryos (Carnegie stages 13 to 23) and in one fetus (10 weeks of gestation). During stages 13-17,no immunoreactivities to S-100α and S-100β were found around the optic vesicle. At stage 18,immunoreactivity to S-100β appeared around the optic vesicles and increased as the embryonic stages advanced. In the fetus, the nerve fibers in the extraocular muscles were slightly immunoreactive to S-100α, but the muscle fibers were not. These findings suggested that extraocular muscles are innervated in the late embryonic period, around stage 18.