ダウンロード数 : ?
言語
英語
属性
Original Article
著者
Fukuyama, Chika
Izumi, Daisuke
Ishikawa, Nahoko
Oka, Akihiko
Mishiro, Tomoko
石原 俊治 医学部内科学講座内科学第二
足立 経一
内容記述(抄録等)
Background
Celiac disease is a chronic autoimmune enteropathy caused by gluten ingestion. While its prevalence in Western countries is reported to be as high as 1%, the prevalence has not been evaluated in a large-scale study of a Japanese population. The aim of our study was to clarify the possible presence of celiac disease in a Japanese non-clinical population as well as in patients showing symptoms suggestive of the disease.

Methods
Serum samples were collected from 2008 non-clinical adults and 47 patients with chronic unexplained abdominal symptoms between April 2014 and June 2016. The anti-tissue transglutaminase (TTG) immunoglobulin A antibody titer was determined as a screening test for celiac disease in all subjects, and individuals with a value of >2 U/mL subsequently underwent testing for the presence of serum endomysial IgA antibody (EMA) as confirmation. Those testing positive for EMA or with a high concentration (>10 U/mL) of TTG were further investigated by histopathological examinations of duodenal mucosal biopsy specimens and HLA typing tests.

Results
Of the 2008 non-clinical adults from whom serum samples were collected, 161 tested positive for TTG, and all tested negative for EMA. Four subjects who had a high TTG titer were invited to undergo confirmatory testing, and the histopathological results confirmed the presence of celiac disease in only a single case (0.05%). Of the 47 symptomatic patients, one (2.1%) was found to have a high TTG titer and was diagnosed with celiac disease based on duodenal histopathological findings.

Conclusion
The presence of celiac disease in a non-clinical Japanese population was low at 0.05% and was rarely found in patients with unexplained chronic abdominal symptoms.
掲載誌名
Journal of Gastroenterology
53
2
開始ページ
208
終了ページ
214
ISSN
0944-1174
ISSN(Online)
1435-5922
発行日
2017-4-7
DOI
出版者
シュプリンガー・ジャパン(株)
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e34597
e34048
e31062
e34482
部局
医学部
備考
日本消化器病学会