Generation and characterization of antagonistic anti-human interleukin (IL)- 18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18

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ファイル	島根大学審査学位論文（k648） 2.65 MB
言語	英語
著者	成相裕子加美野宏樹尾林栄治加藤太陽医学部生化学講座（病態生化学）坂下暁介 Sugiura, Tomoko Department of Biochemistry, Shimane University School of Medicine, Izumo, 693-8501, Japan Migita, Kiyoshi Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan Koga, Tomohiro Department of Rheumatology, Unit of Advanced Preventive Medical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8501, Japan Kawakami, Atsushi Department of Rheumatology, Unit of Advanced Preventive Medical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8501, Japan Sakamoto, Kazuma Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550, Japan Kadomatsu, Kenji Department of Biochemistry, Nagoya University Graduate School of Medicine, 65 Tsurumai-Cho, Showa-Ku, Nagoya, 466-8550, Japan Nakakido, Makoto Department of Bioengineering, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan Tsumoto, Kouhei Department of Bioengineering, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan/Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan 浦野健
発行日	2019-01-04
資料タイプ	学位論文
DOI	10.1016/j.abb.2019.01.001
著者版/出版社版	博士論文全文
部局	医学部
学位授与番号	甲第648号
学位授与年月日	2019-03-22
学位名	博士（医学）
学位授与機関	島根大学
学位論文研究科コード	医学系研究科
学位授与年度	2019
備考	医甲第513号
権利関係（リンク）	This work is licensed under a Creative Commons Attribution 4.0 International License.