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ファイル
言語
日本語
タイトルヨミ
ニンシン ジュニュウ ボタイ ノ シシツ エイヨウ ガ コ ノ イチガタ トウニョウビョウ ハッショウ ヘ オヨボス エイキョウ
日本語以外のタイトル
Maternal intake of essential fatty acid affects development of type 1 diabetes in the offspring
著者
籠橋 有紀子 島根県立大学短期大学部健康栄養学科
内容記述(抄録等)
Human type 1 diabetes is an autoimmune disease resulting from T-cell-mediated destruction of pancreatic islet beta cells. Maternal environment has been suggested to be important in the development of diabetes. In this study, to investigate the effect of maternal nutrition, in particular the essential fatty acid (EFA) ratio (n-6/n-3) and composition, on the development of type 1 diabetes in the offspring, we prepared different kinds of chows with different n-6/n-3 ratios, and provided them to pregnant and lactating mothers and post-weaning female offspring of non-obese diabetic (NOD) mice, a type 1 diabetes model. The EFA ratio in breast milk and serum of NOD dams became nearly the same as that of the maternal diet. Overt diabetes was not suppressed in the offspring from dams provided with a diet with an n-6/n-3 ratio of 14.5 during gestation and lactation, but it was strongly suppressed in those from dams provided with a diet with an n-6/n-3 ratio of 3.0 during the same period. At 2 and 4 weeks after birth, insulin autoantibodies (IAA) were detected in the offspring from dams provided with a diet with an n-6/n-3 ratio of 14.5, and not detected in those from dams provided with a diet with an n-6/n-3 ratio of 3.0. These findings suggest that n-6/n-3 ratio of the maternal diet during gestation and lactation rather than that of the diet intake by offspring after weaning strongly affects the development of overt diabetes in NOD mice.
主題
1型糖尿病
NODマウス
母体栄養
必須脂肪酸
膵島炎
掲載誌名
脂質栄養学
22
1
開始ページ
35
終了ページ
43
ISSN
1343-4594
ISSN(Online)
1883-2237
発行日
2013
DOI
出版者
日本脂質栄養学会
出版者ヨミ
ニホン シシツ エイヨウ ガッカイ
出版者別表記
Japan Society for Lipid Nutrition ©
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e17471
部局
医学部