ダウンロード数 : ?
ファイル
言語
英語
著者
田中 小百合 島根大学医学部内科学第一
金沢 一平 島根大学医学部内科学第一
野津 雅和 島根大学医学部内科学第一
杉本 利嗣 島根大学医学部内科学第一
内容記述(抄録等)
OBJECTIVE: The relationship between serum DPP-4 level and visceral fat mass is still unclear in type 2 diabetes mellitus (T2DM). This study thus aimed to examine the association of visceral fat accumulation and metabolic syndrome with serum DPP-4 levels in T2DM.
METHODS: Visceral and subcutaneous fat areas were evaluated by performing computed tomography scan in 135 men with T2DM, who had never taken DPP-4 inhibitors or GLP-1 receptor agonists. We investigated the association between serum DPP-4 levels and visceral fat area as well as the presence of metabolic syndrome.
RESULTS: Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and HbA1c showed that serum DPP-4 levels were positively associated with visceral fat area (β=0.25, p=0.04), but not subcutaneous fat area (β=-0.18, p=0.13). In logistic regression analyses adjusted for the confounding factors described above, serum DPP-4 levels were positively associated with visceral fat obesity and metabolic syndrome [odds ratio (OR)=1.63, 95% confidence interval (CI)=1.00-2.66 per standard deviation (SD) increase, p=0.04; OR=1.77, 95%CI=1.09-2.88 per SD increase, p=0.02, respectively].
CONCLUSIONS: The present study showed that serum DPP-4 level was positively and specifically associated with accumulation of visceral fat and the presence of metabolic syndrome in men with T2DM.
主題
Dipeptidyl peptidase-4
Visceral fat
Metabolic syndrome
Type 2 diabetes mellitus
掲載誌名
Diabetes research and clinical practice
116
開始ページ
1
終了ページ
6
ISSN
01688227
発行日
2016-06
DOI
DOI公開日
2017-07-18
PubMed ID
NCID
AA1044374X
出版者
Elsevier
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© 2016 Elsevier Ireland Ltd. All rights reserved.
著者版/出版社版
著者版
業績ID
e31960
e32289
部局
医学部