ダウンロード数 : ?
ファイル
言語
英語
著者
Tahara, Nao Department of Neurology, Shimane University, Faculty of Medicine
Matsuda, Hanako Department of Neurology, Shimane University, Faculty of Medicine
Takayoshi, Hiroyuki Department of Neurology, Shimane University, Faculty of Medicine
Yamaguchi, Shuhei Department of Neurology, Shimane University, Faculty of Medicine
内容記述(抄録等)
Objective. We investigated recurrent stroke volume with nonvalvular atrial fibrillation (NVAF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) about clinical backgrounds and number of recurrent stroke.
Methods. We administered four NOACs, dabigatran, rivaroxaban, apixaban and edoxaban in 101 post cardioembolic stroke with NVAF. In retrospective study, we measured recurrent stroke volume with MRI volumetric soft and compared them between 10 vitamin K anticoagulant (VKA: warfarin) cases and 13 NOACs cases under anticoagulant therapy.
Results. Of 101 cases, 31 cases were started with VKA and switched to NOACs after 10 recurrent strokes. Other 70 cases were directly started with NOACs and 13 cases with NOACs as first anticoagulants had recurrent stroke. The frequency of recurrent stroke during anticoagulant therapy are not different among VKA group and three NOACs group. Recurrent stroke volume is significantly larger in VKA group (26.4 cm3) than in NOACs group (3.8cm3).
Conclusions. Secondary prevention with NOACs after stroke might be more beneficial by reducing recurrent infarct volume than VKA.
掲載誌名
Journal of Stroke and Cerebrovascular Diseases
27
2
開始ページ
338
終了ページ
345
ISSN
1052-3057
発行日
2018-02
DOI
PubMed ID
出版者
New York, NY : Demos Publications, [1991-]
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
著者版
業績ID
e31206
部局
医学部