ダウンロード数 : ?
ファイル
言語
英語
属性
原著論文
著者
恒松 晃司
Nakatani Eiji
岩橋 輝明
狩野 正明
成相 義樹
管野 貴浩
Kagimura Tatsuo
内容記述(抄録等)
This preliminary study evaluated the expression of human papilloma virus (HPV) 16, HPV18, and p16 as possible biomarkers to distinguish normal oral epithelium (NOE) from oral epithelial dysplasia (OED) and oral intraepithelial neoplasia (OIN). Subjects comprised 150 cases including 41 with OED, 30 with OIN, and 67 with oral squamous cell carcinoma (OSCC). NOE was also taken from 12 healthy participants. Staining indices of HPV16, HPV18, and p16 were immunohistochemically examined using paraffin-embedded specimens. A statistically significant difference was seen in the expression of HPV18 and p16 in OED/OIN compared with NOE and OSCC. Furthermore, regression tree analysis of independent variables, including p16 and HPV18 expression and the participants’ age, was performed to distinguish NOE from OED/OIN. In conclusion, this preliminary study demonstrated that p16 and HPV18 expression and participants’ age (60 years) can be used to distinguish NOE from OED/OIN.
主題
HPV16 , HPV18 , p16
oral epithelial dysplasia
oral intraepithelial neoplasia
oral squamous cell carcinoma
掲載誌名
Shimane journal of medical science
32
2
開始ページ
69
終了ページ
79
ISSN
03865959
ISSN(Online)
24332410
発行日
2016
NCID
AA00841586
出版者
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e28719
e29188
部局
医学部
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