ダウンロード数 : ?
ファイル
言語
英語
著者
Sugimoto, Naotoshi Department of Physiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920‑8640, Japan.
片倉 賢紀
Wada, Taizo Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920‑8640, Japan.
Yachie, Akihiro Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920‑8640, Japan.
Nakamura, Hiroyuki Department of Public Health Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920‑8640, Japan.
内容記述(抄録等)
The components of ginger root (Zingiber officinale Roscoe) are widely used for various medicinal purposes. Several bioactive compounds have been identified in ginger, including 6‑, 8‑ and 10‑gingerols, and 6‑shogaol, which are agonists of the thermo‑sensors transient receptor potential (TRP) cation channel subfamily V member 1 and TRP ankyrin 1. Our previous study demonstrated that ginger powder may affect human metabolism in vivo. However, the effects of the bioactive compounds of ginger on cells have not been completely elucidated. The present study investigated whether ginger powder extracts could modify cell functions in mouse fibroblast cells. The active components of ginger powder extracts were characterized using high‑performance liquid chromatography. The activation of protein kinases, actin assembly, cell migration, expression levels of heat shock proteins (HSPs) and cell viability after heat shock were analyzed in NIH3T3 mouse fibroblast cells. Subsequently, 6‑, 8‑, 10‑ and 12‑gingerols, as well as 6‑, 8‑ and 10‑shogaols, were detected in ginger powder extracts. The levels of phosphorylated Akt, mTOR, ERK and p38 MAPK increased after a 10‑min stimulation with ginger powder extracts. In addition, HSP expression levels, lamellipodia formation occurring at cell edges, cell migration and tolerance against heat shock were facilitated following ginger powder extract stimulation. These results suggest that ginger modified cell functions, including actin assembly and heat tolerance, in vitro.
掲載誌名
Molecular medicine reports
23
4
ISSN
1791-2997
ISSN(Online)
1791-3004
発行日
2021-02-04
DOI
PubMed ID
出版者
Athens, Greece : D. A. Spandidos
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部