ダウンロード数 : ?
ファイル
言語
英語
著者
Wang, Dan-Qiao
Kakizoe, Eiichi
下浦 惠子
小林 裕太
奥西 秀樹
内容記述(抄録等)
Trandolapril, an angiotensin-converting enzyme (ACE) inhibitor, has been reported to have higher efficiency on tissue ACE than other ACE inhibitors. In this study, effect of trandolapril on pressure-overload cardiovascular hypertrophy in early stage was examined in rats by comparing with the effect of enalapril. Rats with abdominal aorta banded or sham-operated were orally treated with trandolapril (1 mg/kg/day), enalapril (2O mg/kg/day), or vehicle for 2 weeks after the surgical maneuvers. In vehicle-treated rats, the banding raised intra-aortic pressure, maximum velocity ofpressure rise, left ventricular (LV) weight, LV ACE activity, and aortic mass. Although both ACE iuhibitors equally reduced the aortic pressure, only trandolapril elicited a significant prevention of the aortic hypertrophy. In contrast, cardiac hypertrophy was insignificantly prevented by either inhibitor. The LV ACE activity was completely inhibited by traldolapril, whereas insignificantly suppressed by enalapril. These results suggest that effective inhibition of tissue ACE attenuates the 2-week pressure overload-induced hypertrophy of the aorta but not of the LV.
掲載誌名
Shimane journal of medical science
17
2
開始ページ
51
終了ページ
59
ISSN
03865959
ISSN(Online)
24332410
発行日
1999-12-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e19120
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
他の一覧