ファイル
言語
英語
属性
原著論文
著者
Yasumoto, Ko
多田納 豊
清水 利朗
富岡 治明
内容記述(抄録等)
We studied roles of phospholipase A2 (PLA2) isozymes, including type IIA secretory PLA2 (sPLA2-IIA), type IV cytosolic, Ca2+-dependent PLA2 (cPLA2) , type V secretory PLA2 (sPLA2-V) , and type VI cytosolic, Ca2+-independent PLA2 (iPLA2) , in macrophage (Mφ) antimicrobial activity against Mycobacterium tuberculosis (Mtb) H37Ra (avirulent) strain and Mφ mRNA expression of these PLA2 isotypes in response to infection with the microorganisms. First, a cPLA2 inhibitor arachidonyl trifluoromethylketone mildly reduced Mφ anti-Mtb activity, while the other PLA2 inhibitors did not significantly block the Mφ antimycobacterial function, if any. Second, Mφ expression of cPLA2 and sPLA2-V mRNAs was up-regulated during 6 to 12 h after infection with Mtb H37Ra strain. These findings suggest that cPLA2 plays a role in cellular mechanisms participating in the expression of Mφ anti-Mtb activity.
掲載誌名
Shimane journal of medical science
27
開始ページ
17
終了ページ
24
ISSN
03865959
ISSN(Online)
24332410
発行日
2010-12-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html