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ファイル
言語
英語
著者
家森 幸男
大高 道也
奈良 安雄
堀江 良一
大島 章
Endo Takeshi
内容記述(抄録等)
Spontaneously hypertensive rats (SHR) showed a mild deviation of glucose metabolism, as detected by glucose tolerance test (GTT).The morphological changes in the pancreatic islets of SHR may possibly be related to the hormonal alteration in genetic hypertension.In light of these experimental results GTT was applied for study in the following 3 groups of humans : the normotensives with or without a family history of cerebral stroke (5 each) and 5 hypertensives with no apparent secondary cause.
Higher serum glucose and insulin levels were obtained et 1 hour of GTT both in the hypertensives and the normotensives with a family history of cerebral stroke.
Serum lipid levels were altered by glucose administration, particularly serum cholesterol level was decreased by about 10 mg/dl at 1 hour after glucose administration both in rats and humans, with or without hypertension.
The slight intolerance detected by GTT in genetic hypertension both in rats and humans may be used as a parameter in the detection of genetic predisposition to hypertension or cerebral stroke.
主題
hypertension
glucose tolerance
insulin
掲載誌名
Shimane journal of medical science
2
2
開始ページ
124
終了ページ
132
ISSN
03865959
ISSN(Online)
24332410
発行日
1978-12-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
他の一覧