ダウンロード数 : ?
ファイル
言語
英語
著者
内容記述(抄録等)
Activated glial cells are capable of generating various inflammatory mediators, including cytokines, nitric oxide and reactive oxygen species. These potentially neurotoxic molecules have been suggested to play a role in the etiology and development of depression. Accumulating evidence indicates that antidepressants have inhibitory effects on inflammatory activation of glial cells and confer neuroprotection under neuropathological conditions. Such efficacy of antidepressants appears to depend on suppressing microglial production of inflammatory substances and up-regulating both astrocytic secretion of neurotrophins and astrocytic glutamine synthase, which converts neurotoxic glutamate into non-toxic glutamine. Therefore, glial cells, both as source and target of inflammatory molecules, may represent a potential promising target involved in the pathophysiology of depression. Moreover, antidepressants have the possibility to be useful treatment, not only for depression, but for a broad spectrum of neuroinflammatory and neurodegenerative disorders where the pathogenesis is associated with glial activation.
主題
Antidepressants
anti-inflammatory effect
astrocyte
cytokine
depression
microglia
nitric oxide
reactive oxygen species
掲載誌名
Current Drug Targets
14
11
開始ページ
1322
終了ページ
1328
ISSN
1389-4501
ISSN(Online)
1873-5592
発行日
2013
DOI
出版者
Bentham Science Publishers
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
業績ID
e21724
部局
医学部