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ファイル
言語
英語
属性
総説
著者
内容記述(抄録等)
Both the disruption of endothelial homeostasis and tissue fibrosis are characteristics of diabetic complications. Accumulating evidence has revealed the significant role of vascular endothelial cells in tissue fibrogenesis via endothelial-mesenchymal transition (EndMT).
We have recently focused on the overexpression of endothelial dipeptidyl peptidase (DPP)-4, a critical pathological feature of the molecular mechanisms of EndMT, and suggest that DPP-4 inhibitors have great therapeutic potential via their antifibrotic effects. However, the diverse pleiotropic effects of DPP-4, both its enzyme-dependent and enzyme-independent effects, can be detrimental in some cases. This review provides an update on the biology of DPP-4, a profibrotic molecule, in addition to a discussion of cancer biology.
主題
fibrosis
microRNA
integrin
extracellular matrix
cancer
掲載誌名
Shimane Journal of Medical Science
36
2-3
開始ページ
33
終了ページ
40
ISSN
03865959
ISSN(Online)
24332410
発行日
2019-12
NCID
AA00841586
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
著者版/出版社版
出版社版
部局
医学部