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ファイル
言語
英語
著者
八田 稔久
田中 修
内容記述(抄録等)
The amino acid sequence arginine-glycine-aspartate (RGD) acts as a specific ligand for integrins in cell adhesion. We injected RGD into the telencephalic vesicle of mouse embryos exo utero on E13 and examined the cortical histogenesis of the telencephalon on E15,16 and 18. RGD induced disorganized cytoarchitecture and reduced cell number in the cortical plate and intermediate zone. In the ventricular zone although there was no difference in cell density between RGD-injected brains and controls, mitotic activity analysis revealed the lower proliferative rate in RGD-injected brains. These results suggest that RGD-proteins or integrins play an important role both in the migration of neuroblasts and the proliferation of neuroepithelial cells during the cortical histogenesis of the telencephalon.
主題
RGD peptide
Neurogenesis
Exo utero development
Mouse embryo
掲載誌名
Shimane journal of medical science
14
開始ページ
1
終了ページ
6
ISSN
03865959
ISSN(Online)
24332410
発行日
1996
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
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