ダウンロード数 : ?
ファイル
言語
英語
著者
田中 賢一郎
内容記述(抄録等)
Sarcopenia has recently attracted widespread attention, because it increases risks of fall and bedridden. Although patients with type 2 diabetes mellitus (T2DM) are known to have lower muscle mass of limbs than healthy people, the mechanism is still unclear. We thus examined the association of muscle mass with parameters of endogenous insulin secretion such as fasting immunoreactive insulin, fasting C-peptide immunoreactivity (CPR), and daily urine CPR in 191 men with T2DM. Muscle mass of arms and legs was evaluated by dual-energy X-ray absorptiometry, and we calculated relative skeletal muscle index (RSMI), which is useful for the diagnosis of sarcopenia. Multiple regression analyses adjusted for age, duration of T2DM, serum creatinine, HbA1c, and insulin-like growth factor-I showed that each parameter of endogenous insulin was significantly and positively correlated with muscle mass of arms and legs as well as RSMI (p < 0.05). Moreover, logistic regression analyses adjusted for confounding factors mentioned above showed that each parameter of endogenous insulin was significantly lower in subjects with sarcopenia than those without it (p < 0.05). In conclusion, reduction in endogenous insulin secretion is an independent risk factor of sarcopenia in men with T2DM.
主題
Sarcopenia
Insulin secretion
Diabetes mellitus
Skeletal muscle mass
IGF-Ι
掲載誌名
Calcified Tissue International and Musculoskeletal Research
97
4
開始ページ
385
終了ページ
390
ISSN
0171967X
発行日
2015-10
DOI
DOI公開日
2017-04-10
PubMed ID
出版者
Springer US
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
The final publication is available at Springer via http://dx.doi.org/10.1007/s00223-015-9990-8.
著者版/出版社版
著者版
業績ID
e28545
e28619
部局
医学部
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